Infant predictors of autism spectrum disorder

Author/s
Teodora Gliga, Mark Johnson
Citation
Issue 4 Summer 2014
CEPiP.2014.1.52-55
Abstract

The study of infants at familial risk for developing autism has revealed a variety of early brain and behavioural markers for this disorder. Brain connectivity, processing of gaze direction, attention shifting or reacting to sensory stimulation are all atypical during the first year of life in those high-risk infants who later develop symptoms of autism. Future research will have to determine whether these early signs are predictive of autism outside populations at risk and whether they are specific to autism.

Cite as: Cutting Edge Psychiatry in Practice 2014, 4(1):52-55; https://doi.org/10.65031/lskk1886

References

  1. Daniels AM, Mandell, DS. Explaining differences in age at autism spectrum disorder diagnosis: A critical review. Autism 2013; 18(5) 583-597. https://doi.org/10.1177/1362361313480277
  2. Charman T. Early Screening for Autism, Cutting Edge Psychiatry in Practice 2014; 4; (This issue)
  3. Hallmeyer, J., Cleverland, S., Torres, A., Phillips, J. et al Genetic heritability and shared environmental factors among twin pairs with autism. JAMA Psychiatry 2011; 68(11): 1095-1102 https://doi.org/10.1001/archgenpsychiatry.2011.76
  4. Ronald A, Pennell CE, Whitehouse AJO. Prenatal Maternal Stress Associated with ADHD and Autistic Traits in early Childhood. Front Psychol 2010; 1:223 https://doi.org/10.3389/fpsyg.2010.00223
  5. Palomo R, Belinchón M, Ozonoff S. Autism and Family Home Movies: A Comprehensive Review Journal of Developmental & Behavioral Pediatrics 2006; 27(2):S59-S68 https://doi.org/10.1097/00004703-200604002-00003
  6. Messinger D. Beyond Autism: A Baby Siblings Research Consortium Study of High-Risk Children at Three Years of Age. Journal of the American Academy of Child & Adolescent Psychiatry 2013; 52 (3): 300 - 308 https://doi.org/10.1016/j.jaac.2012.12.011
  7. Johnson MH. Developmental Cognitive Neuroscience. Wiley-Blackwell; 3rd Edition edition (10 Sep 2010)           
  8. Shen MD, Nordahl CW, Young GS, Wootton-Gorges SL, Lee A, Liston SE, Harrington KR, Ozonoff S and Amaral DG. Early brain enlargement and elevated extra-axial fluid in infants who develop autism spectrum disorder Brain 2013; Epub. July, doi: 10.1093/brain/awt166. https://doi.org/10.1093/brain/awt166
  9. Wolff, JJ, Gu H, Gerig G and Elison JT. Differences in white matter fiber tract development present from 6 to 24 months in infants with autism. American Journal of Psychiatry 2012; 169: 589-600. https://doi.org/10.1176/appi.ajp.2011.11091447
  10. Elsabbagh M, Gliga T, Pickles A, Hudry K, Charman T, Johnson MH; BASIS Team. The development of face orienting mechanisms in infants at-risk for autism. Behav Brain Res. 2013 Aug 15;251:147- 54. doi: 10.1016/j.bbr.2012.07.030. Epub 2012 Jul 27. https://doi.org/10.1016/j.bbr.2012.07.030
  11. Chawarska K, Macari S, Shic F. Decreased spontaneous attention to social scenes in 6-month-old infants later diagnosed with autism spectrum disorders. Biol Psychiatry. 2013 Aug 1;74(3):195-203. doi: 10.1016/j.biopsych.2012.11.022. Epub 2013 Jan 11. https://doi.org/10.1016/j.biopsych.2012.11.022
  12. Young GS, Merin N, Rogers SJ, Ozonoff S. Gaze behavior and affect at 6 months: predicting clinical outcomes and language development in typically developing infants and infants at risk for autism. Dev Sci. 2009 Sep;12(5):798-814. doi: 10.1111/j.1467-7687.2009.00833.x. https://doi.org/10.1111/j.1467-7687.2009.00833.x
  13. Elsabbagh M, Bedford R, Senju A, Charman T, Pickles A, Johnson MH; BASIS Team. What you see is what you get: contextual modulation of face scanning in typical and atypical development. Soc Cogn Affect Neurosci. 2014 Apr;9(4):538-43. doi: 10.1093/scan/nst012. Epub 2013 Feb 5. https://doi.org/10.1093/scan/nst012
  14. Ozonoff, S. et al. A Prospective Study of the Emergence of Early Behavioral Signs of Autism. JAAC 49, 256–266.e2 (2010).   
  15. Elsabbagh M, Mercure E, Hudry K, Charman T, Pickles A, Baron-Cohen S, Bolton P, Johnson MH, and The BASIS Team. Infant Neural Sensitivity to Dynamic Eye Gaze Is Associated with Later Emerging Autism. Current Biology 2012; 22, 338-342 https://doi.org/10.1016/j.cub.2011.12.056
  16. Elsabbagh M, Fernandes J, Webb SJ, Dawson G, Charman T, Johnson M, The BASIS Team. Disengagement of visual attention in infancy is associated with emerging autism in toddlerhood. Biological Psychiatry 2013; 3(1), 189-194 https://doi.org/10.1016/j.biopsych.2012.11.030
  17. Elison JT, Paterson SJ, Wolff JJ, Reznick JS, Sasson NJ, Gu H, Botteron KN, Dager SR, Estes AM, Evans AC, Gerig G, Hazlett HC, Schultz RT, Styner M, Zwaigenbaum L, Piven J; IBIS Network. White matter microstructure and atypical visual orienting in 7-month-olds at risk for autism. Am J Psychiatry. 2013 Aug 1;170(8):899-908. doi: 10.1176/appi.ajp.2012.12091150. https://doi.org/10.1176/appi.ajp.2012.12091150
  18. Clifford SM, Hudry K, Elsabbagh M, Charman T, Johnson MH; BASIS Team. Temperament in the first 2 years of life in infants at high-risk for autism spectrum disorders. J Autism Dev Disord. 2013 Mar;43(3):673-86. doi: 10.1007/s10803-012-1612-y. https://doi.org/10.1007/s10803-012-1612-y
  19. Flanagan, JE, Landa R, Bhat, AN, Bauman, M. Head Lag in Infants at Risk for Autism: A Preliminary Study. The American Journal of Occupational Therapy 2012; 66: 577-585. https://doi.org/10.5014/ajot.2012.004192
  20. Russell G, Rodgers LR, Ukomunne OC, Ford T. Prevalence of parent-reported ASD and ADHD in the UK: Findings from the Millenium Cohort Study. Journal of Autism and Developmental Disorders 2014; 44(1), 32-40. https://doi.org/10.1007/s10803-013-1849-0
  21. Russell G, Rodgers LR, Ukoumunne OC, Ford T. Prevalence of parent-reported ASD and ADHD in the UK: findings from the Millennium Cohort Study. J Autism Dev Disord. 2014 Jan;44(1):31-40. doi:10.1007/s10803-013-1849-0. https://doi.org/10.1007/s10803-013-1849-0