Genetics, epigenetics and BDNF in depression

Author/s
Jurij Bon, Peter Pregelj, Alija Videtic Paska
Citation
Issue 5 Winter 2018
CEPiP.2018.1.20-25
Abstract

Major depressive disorder is a multifactorial psychiatric disorder, in which different genetic, epigenetic and environmental factors play a causal role. We discuss novel findings in the genetics and epigenetics of depression, with special emphasis on the role of the brain derived neurotrophic factor (BDNF). Many stud¬ies show changes in BDNF levels as a result of treatment for depression, including as a result of treatment with non-brain stimulation. We highlight the role of BDNF as a possible biomarker of depression and an indicator of treatment response to antidepressant medication or non-invasive brain stimulation.

Cite as: Cutting Edge Psychiatry in Practice 2018, 5(1):20-25; https://doi.org/10.65031/wnaw3258

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