The practical application of individual cognitive behaviour therapy (CBT) as a recommended, firstline, evidence-based, therapeutic intervention for adults with depression is considered and described in this paper. Some of the contemporary evidence supporting the provision of CBT for depression, and the characteristic principles, features, and care processes involved in providing this highly-collaborative, formulation-driven, recovery-focused approach are highlighted, with reference to short illustrative examples. As shown, practical application involves a structured and detailed assessment that is used in collaboratively developing a formulation as the basis for treatment planning and intervention. Central to this therapeutic approach, formulation leads to the careful selection and tailoring of specific cognitive and behavioural strategies, several of which are briefly outlined, with suggestions for accessing practical resources. In deciding whether or not to offer this intervention, a series of suitability factors should be considered, in addition to the availability of a well-trained and supervised therapist/practitioner.